The Link Between Constipation and Semaglutide Use in Patients with Overweight or Obesity Semaglutide, a glucagon-like peptide-1 (GLP-1) receptor agonist, has been heralded as a game-changer in the management of obesity. While its efficacy in promoting weight loss is well-documented, there is an emerging conversation within the medical community about its gastrointestinal side effects, particularly constipation. This article aims to provide health professionals with a comprehensive understanding of the evidence linking semaglutide to constipation and its implications on gut health. Understanding Semaglutide Semaglutide is a once-weekly injectable medication that mimics the functions of the natural hormone GLP-1. It works by enhancing insulin secretion, inhibiting glucagon release, and slowing gastric emptying. These mechanisms collectively contribute to appetite suppression and significant weight loss. However, the slowing of gastric emptying can also lead to gastrointestinal disc...