The Role of Gut Serotonin in GI Motility and Intestinal Crosstalk with Microbiota Serotonin, also known as 5-hydroxytryptamine (5-HT), is mainly synthesized in the gastrointestinal (GI) tract. It has been studied for decades as it plays a crucial role in regulating the different neurogenic motor patterns in the GI tract. Recently, two separate studies by Keating, Damien J., and Ge, Xiaolong, have shed some light on the connection between gut serotonin and microbiota, and their impact on GI motility. In this blog post, we will dive deeper into these studies, and explore the scientific evidence behind the claims. One of the primary studies we will discuss is Keating, Damien J.'s article, "Gut Serotonin in the Control of Gastrointestinal Motility." The study highlights the essential role that serotonin plays in the control of gastrointestinal motility. It found that serotonin is synthesized in the enterochromaffin cells of the intestinal mucosa, via the enzyme tryptophan h