Top 5 Neurotransmitters That Control Gut Motility — And Natural Ways to Support Digestive Health The digestive system relies on more than muscles and enzymes to keep food moving. Behind the scenes, a network of nerves and chemical messengers called neurotransmitters directs when muscles should contract, relax, or secrete fluids. This process, known as gut motility, is essential for proper digestion and waste elimination. When motility is disrupted, symptoms such as bloating, constipation, diarrhea, or abdominal discomfort often follow. Understanding how neurotransmitters regulate these processes—and how natural approaches can support them—offers a practical path to better gut health. 1. Acetylcholine (ACh) – The Activator Acetylcholine is the main excitatory neurotransmitter in the gut. It stimulates smooth muscle contractions, increases peristalsis, and enhances digestive secretions. Low acetylcholine activity is often linked to constipation and reduced bowel movements. Na...